Table of Contents > Interactions & Depletions > Ashwagandha (Withania somnifera, Physalis somnifera) Print

Ashwagandha (Withania somnifera, Physalis somnifera)



Depletions

Ashwagandha/Nutrient Depletion:
  • 5-Hydroxytryptophan (5-HTP)5-Hydroxytryptophan (5-HTP): Reduced 5-HTP levels were associated with 12 weeks of ashwagandha therapy in patients with anxiety (41).
  • GlucoseGlucose: Ashwagandha may lower blood sugar levels, according to limited human research (in patients with type 2 diabetes), although the mechanism is unknown (38; 12; 60).
  • LipidsLipids: In a case series, ashwagandha significantly decreased serum total cholesterol levels, triglycerides, low-density lipoprotein (LDL), and very-low-density lipoproteins (VLDL) (38). In humans, serum cholesterol decreased in a statistically significant manner after ashwagandha use (31).
  • PotassiumPotassium: In humans, ashwagandha decreased serum sodium and potassium while urine sodium and volume increased (38).
  • SodiumSodium: In humans, ashwagandha decreased serum sodium and potassium while urine sodium and volume increased (38).

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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