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Related terms
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    Related terms
    • Brand Names: U.S.: Afinitor®;Zortress®
    • Brand Names: Canada: Afinitor®
    • Pharmacologic Category: Antineoplastic Agent, mTOR Kinase Inhibitor;Immunosuppressant Agent;mTOR Kinase Inhibitor

    • It is used to treat some cancers.
    • It is used to keep the body from turning down the organ after an organ transplant.
    • Everolimus harms cancer cells stopping their growth.
    • It slows the growth or spread of cancer cells.
    • It helps the body accept an organ transplant.


    How to take

    • To gain the most benefit, do not miss doses.
    • Take this drug at the same time of day.
    • Take with a full glass of water.
    • Take with or without food. Take with food if it causes an upset stomach.
    • Swallow whole. Do not chew, break, or crush.
    • You may crush the tablet and mix it with 2 tablespoons (30 mL) of water if you are not able to swallow it whole.
    • Take Zortress® at the same time as you take cyclosporine.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it has been 6 hours or more since the missed dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.


    • Store at room temperature.
    • Protect from light.
    • Protect from water. Do not store in a bathroom or kitchen.



    • Long-term use may raise the chance of cancer and unsafe infections.
    • Unsafe side effects may happen. This drug cannot be taken while you are taking some other drugs. Check all the drugs you are taking with your doctor.
    • Zortress®
    • A blood clot may happen in your kidney transplant. Call your doctor right away if you have back or belly pain, are not able to pass urine, have blood in your urine, a fever, an upset stomach, or you are throwing up.
    • If you are taking this drug with cyclosporine, you will need a lower dose of cyclosporine. Talk with your doctor.
    • Please read the medication guide.


    • If you have an allergy to everolimus, temsirolimus, sirolimus, or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.


    • There is a chance of skin cancer. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
    • The chance of cancer is higher after using this drug.
    • If you have high blood sugar (diabetes), talk with your doctor.
    • If you have high cholesterol, talk with your doctor.
    • If you have liver disease, talk with your doctor.
    • Have your blood work checked often. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Do not take St John's wort with this drug. This drug may not work as well.
    • Avoid grapefruit and grapefruit juice.
    • Tell dentists, surgeons, and other doctors that you use this drug.
    • Talk with your doctor before getting any vaccines. Use with this drug may either raise the chance of a very bad infection or make the vaccine not work as well.
    • Use birth control that you can trust, during care, and for 2 months after care ends.

    Side Effects

    • Chance of getting an infection. Avoid people with infections, colds, or flu.
    • Anemia, low white blood cell count, and low platelet count.
    • High cholesterol level.
    • High blood sugar. This most often goes back to normal when drug is stopped.
    • High blood pressure.
    • Swelling.
    • Feeling tired or weak.
    • Fever.
    • Headache.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Mouth irritation. Using a soft toothbrush or cotton swabs and rinsing the mouth may help.
    • Loose stools.
    • Not hungry.
    • Dry mouth. Good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. See a dentist often.
    • Belly pain.
    • Bad taste in your mouth. This most often goes back to normal.
    • Harm to the lungs may rarely happen.
    • Kidney failure may rarely happen.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
    • Trouble breathing.
    • Chest pain.
    • Very bad belly pain.
    • Very upset stomach or throwing up.
    • Very loose stools.
    • Any bruising or bleeding.
    • Very bad mouth irritation.
    • Very bad back pain.
    • Blood in the urine.
    • Not able to pass urine.
    • Skin wound that will not heal.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

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    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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