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Ambrisentan

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Letairis®
    • Brand Names: Canada: Volibris®
    • Pharmacologic Category: Endothelin Antagonist;Vasodilator

    Uses
    • It is used to treat high pressure in the lungs.
    • Ambrisentan blocks a chemical in the blood that causes blood vessels to narrow.

    Dosing

    How to take

    • Take this drug at the same time of day.
    • To gain the most benefit, do not miss doses.
    • Take with or without food. Take with food if it causes an upset stomach.
    • Swallow tablet whole. Do not chew, break, or crush.
    • If you are a woman of childbearing age, take a pregnancy test before starting this drug.
    • If you are a woman of childbearing age, take a monthly pregnancy test.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.

    Storage

    • Store at room temperature.
    • Protect from water. Do not store in a bathroom or kitchen.

    Safety



    Warnings

    • You cannot get this drug from your pharmacy. It comes only from the company that makes it.
    • Do not take if you are pregnant.
    • Please read the medication guide.

    Avoid

    • If you have an allergy to ambrisentan or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.

    Precautions

    • If you have liver disease, talk with your doctor.
    • Have your blood work checked. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Avoid grapefruit and grapefruit juice.
    • Avoid or limit drinking wine, beer, or mixed drinks to less than 3 drinks a day. Drinking too much alcohol may raise your chance of liver disease.
    • Use 2 kinds of birth control that you can trust during care and for 1 month after care ends.

    Side Effects

    • Headache.
    • Flushing.
    • Swelling in the arms or legs.
    • Sore throat.
    • Not able to get a woman pregnant.
    • Anemia may rarely happen.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Trouble breathing.
    • A fast heartbeat.
    • Very bad belly pain.
    • Very upset stomach or throwing up.
    • Not able to eat.
    • Dark urine or yellow skin or eyes.
    • Feeling very tired or weak.
    • A big weight gain.
    • For women, if you get pregnant while taking this drug.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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