Table of Contents > Drug > Metronidazole (Systemic) Print

Metronidazole (Systemic)

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Flagyl®;Flagyl® 375;Flagyl® ER
    • Brand Names: Canada: Apo-Metronidazole®;Flagyl®;Florazole® ER
    • Pharmacologic Category: Amebicide;Antibiotic, Miscellaneous;Antiprotozoal, Nitroimidazole

    Uses
    • It is used to stop or treat GI (gastrointestinal) ulcers caused by infection.
    • It is used to treat bacterial infections.
    • Metronidazole works to harm the bacteria and fight the infection.

    Dosing

    How to take

    • To gain the most benefit, do not miss doses.
    • Use as you have been told, even if you are feeling better.
    • Oral:
    • Take with or without food. Take with food if it causes an upset stomach.
    • Take long-acting products on an empty stomach. Take 1 hour before or 2 hours after meals.
    • Shot:
    • It is given as a shot into a vein.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.

    Storage

    • Store at room temperature.
    • Protect capsules and tablets from water. Do not store in a bathroom or kitchen.
    • Follow how to store the shot closely. Talk with the doctor.

    Safety



    Warnings

    • Metronidazole has been shown to cause cancer in mice and rats. Talk with the doctor.
    • Unsafe side effects may happen. This drug cannot be taken while you are taking some other drugs. Check all the drugs you are taking with your doctor.

    Avoid

    • If you have an allergy to metronidazole or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you are less than 12 weeks pregnant.
    • If you are breast-feeding.

    Precautions

    • If you have a blood disease, talk with your doctor.
    • If you have liver disease, talk with your doctor.
    • If you have seizures, talk with your doctor.
    • If you are taking a blood thinner, have your blood work checked. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Avoid beer, wine, or mixed drinks. Do not take alcohol for at least 24 hours after the last dose. Drinking alcohol or products that have alcohol, such as cough syrup, may cause cramps, upset stomach, headaches, and flushing.
    • Birth control pills and other hormone-based birth control may not work to stop pregnancy. Use some other kind of birth control while taking this drug.
    • Tell your doctor if you are pregnant or plan on getting pregnant.

    Side Effects

    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Loose stools. Yogurt or probiotics may help. You may get these products at health food stores or in some pharmacies.
    • Headache.
    • Not hungry.
    • Bad taste in your mouth. This most often goes back to normal.
    • Change in color of urine to black or brown.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Very bad dizziness.
    • Very bad headache.
    • Trouble speaking.
    • Seizures.
    • Very loose stools, even after drug is stopped.
    • Numbness or tingling in your hands or feet.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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