Table of Contents > Drug > Amitriptyline and Perphenazine Print

Amitriptyline and Perphenazine

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: Canada: PMS-Levazine
    • Pharmacologic Category: Antidepressant, Tricyclic (Tertiary Amine);Antipsychotic Agent, Typical, Phenothiazine

    Uses
    • It is used to treat low mood (depression).
    • It is used to treat anxiety.
    • Amitriptyline raises chemicals in the brain.
    • Perphenazine helps clear thinking.
    • With low mood (depression), sleep and eating habits may get better fast. Other signs may take up to 4 to 6 weeks to get better.

    Dosing

    How to take

    • Take with or without food. Take with food if it causes an upset stomach.
    • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.

    Storage

    • Store at room temperature.
    • Protect from light.
    • Protect from water. Do not store in a bathroom or kitchen.

    Safety



    Warnings

    • The want to harm yourself is an unsafe sign of low mood (depression). It may last until your low mood is fully treated. If you are planning on harming yourself, call the ER (emergency department) right away.
    • There is a higher chance of death in older adults who take this drug for memory problems (dementia).
    • Unsafe side effects may happen. This drug cannot be taken while you are taking some other drugs. Check all the drugs you are taking with your doctor.
    • Please read the medication guide.

    Avoid

    • If you have an allergy to amitriptyline, perphenazine, or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Bone marrow disease or recent heart attack.
    • If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this drug is started. Taking both at the same time could cause risky high blood pressure.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.

    Precautions

    • If you are 65 or older, use this drug with care. You could have more side effects.
    • If you have been taking this drug for many weeks, talk with your doctor before stopping. You may want to slowly stop this drug.
    • If you have high blood sugar (diabetes), talk with your doctor.
    • If you have heart disease, talk with your doctor.
    • If you have kidney disease, talk with your doctor.
    • If you have liver disease, talk with your doctor.
    • If you have myasthenia gravis, talk with your doctor.
    • If you have Parkinson's disease, talk with your doctor.
    • If you have seizures, talk with your doctor.
    • If you have an overactive thyroid, talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • You may not be alert. Avoid driving and doing other tasks or actions until you see how this drug affects you.
    • Avoid beer, wine, mixed drinks, or other drugs and natural products that slow your actions.
    • Avoid grapefruit and grapefruit juice.
    • You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
    • Be careful in hot weather. Drink lots of fluids to stop fluid loss.
    • Use birth control that you can trust to stop pregnancy while taking this drug.

    Side Effects

    • Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.
    • Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing.
    • Nervous and excitable.
    • Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative.
    • Dry mouth. Good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. See a dentist often.
    • Weight gain.
    • Change in sex ability. This most often goes back to normal.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • If you are planning to harm yourself or the want to harm yourself gets worse.
    • Very bad dizziness or passing out.
    • Change in thinking clearly and with logic.
    • Shakiness, trouble moving around, or stiffness.
    • Very nervous and excitable.
    • Not able to pass urine.
    • Feeling very tired or weak.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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