Table of Contents > Drug > Asparaginase (E. coli) Print

Asparaginase (E. coli)

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Elspar®
    • Brand Names: Canada: Kidrolase®
    • Mexican Brand Names: Elspar
    • Pharmacologic Category: Antineoplastic Agent, Miscellaneous;Enzyme

    Uses
    • It is used to treat leukemia.
    • It is used to treat lymphoma.
    • Asparaginase harms cancer cells causing their death.

    Dosing

    How to take

    • It is given as a shot into a muscle, vein, or into the fatty part of the skin.

    Missed Dose

    • Call your doctor for an office visit.

    Storage

    • This drug will be given to you in a hospital or doctor's office. You will not store it at home.

    Safety



    Warnings

    • Unsafe allergic effects may happen. Tell your doctor about any fever, rash, feeling tired, upset stomach, throwing up, loose stools, belly pain, flu-like signs, sore throat, cough, or trouble breathing. Do not restart this drug if you have had an allergic reaction.
    • Unsafe side effects may happen. This drug cannot be taken while you are taking some other drugs. Check all the drugs you are taking with your doctor.

    Avoid

    • If you have an allergy to asparaginase or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If this drug caused bleeding, a blood clot, or an irritated pancreas before.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.

    Precautions

    • Talk with your doctor before getting any vaccines. Use with this drug may either raise the chance of a very bad infection or make the vaccine not work as well.
    • If you have any blood flow problems, talk with your doctor.
    • If you have high blood sugar (diabetes), talk with your doctor.
    • If you have pancreatic disease, talk with your doctor.
    • Have your blood work checked often. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
    • Tell dentists, surgeons, and other doctors that you use this drug.
    • Take good care of your teeth. See a dentist often.
    • Use birth control that you can trust to stop pregnancy while taking this drug.
    • If you are a man and have sex, protect your partner from pregnancy. Use birth control that you can trust.

    Side Effects

    • Fever and chills while this drug is being given. Other drugs may be given to avoid these.
    • Bleeding problems.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • High blood sugar. This most often goes back to normal when drug is stopped.
    • Seizures may rarely happen.
    • Unsafe allergic effects may rarely happen.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
    • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
    • Change in thinking clearly and with logic.
    • Very upset stomach or throwing up.
    • Very bad belly pain.
    • Not able to eat.
    • Any bruising or bleeding.
    • Dark urine or yellow skin or eyes.
    • Feeling very tired or weak.
    • More trips to the bathroom, more thirst, or weight loss.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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