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Bevacizumab

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Avastin®
    • Brand Names: Canada: Avastin®
    • Mexican Brand Names: Avastin
    • Pharmacologic Category: Antineoplastic Agent, Monoclonal Antibody;Vascular Endothelial Growth Factor (VEGF) Inhibitor

    Uses
    • It is used to treat some cancers.
    • It is used to treat macular degeneration.
    • Bevacizumab stops blood flow to tumors, starving them.
    • It slows eyesight loss.

    Dosing

    How to take

    • It is given as a shot into a vein over a period of time.
    • It is given as a shot into the eye.

    Missed Dose

    • Call your doctor for an office visit.

    Storage

    • This drug will be given to you in a hospital or doctor's office. You will not store it at home.

    Safety



    Warnings

    • Unsafe holes in the GI (gastrointestinal) tract, wounds not fully healed, fistulas, and very bad bleeding have been reported. Talk with your doctor.
    • Unsafe side effects may happen. This drug cannot be taken while you are taking some other drugs. Check all the drugs you are taking with your doctor.

    Avoid

    • If you have an allergy to bevacizumab or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.

    Precautions

    • Shot:
    • If you have heart disease, talk with your doctor.
    • If you have had blood clots, talk with your doctor.
    • If you have high blood pressure, talk with your doctor.
    • Have your blood pressure checked often. Talk with your doctor.
    • Have your blood work checked often. Talk with your doctor.
    • Have your urine checked. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Tell dentists, surgeons, and other doctors that you use this drug.
    • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
    • Talk with your doctor before using other aspirin, products that have aspirin, blood thinners, garlic, ginseng, ginkgo, ibuprofen or like products, pain drugs, or vitamin E.
    • Use birth control that you can trust to stop pregnancy.
    • Eye:
    • If you have glaucoma, talk with your doctor.

    Side Effects

    • Shot:
    • Bleeding problems.
    • Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing.
    • Headache.
    • Belly pain.
    • Back pain.
    • High or low blood pressure.
    • Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Loose stools.
    • Feeling tired or weak.
    • Not hungry.
    • Tearing.
    • A wound that does not heal.
    • Skin irritation.
    • Eye:
    • More eye pressure.
    • Eye infection.
    • Eye irritation.
    • Blurred eyesight. Use care when driving or doing other tasks that call for clear eyesight.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Very bad dizziness or passing out.
    • Trouble breathing.
    • Swelling in your legs or belly.
    • Very bad headache.
    • Seizures.
    • High fever.
    • Change in thinking clearly and with logic.
    • Sudden change in eyesight, eye pain, or irritation.
    • Very upset stomach or throwing up.
    • Very hard stools (constipation).
    • Very bad belly pain.
    • Very loose stools.
    • Numbness or tingling in your hands or feet.
    • Skin wound that will not heal.
    • Cloudy or pink-red urine.
    • Any bruising or bleeding.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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