Table of Contents > Drug > Clozapine Print

Clozapine

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Clozaril®;FazaClo®
    • Brand Names: Canada: Apo-Clozapine®;Clozaril®;Gen-Clozapine
    • Mexican Brand Names: Clopsine;Leponex
    • Pharmacologic Category: Antipsychotic Agent, Atypical

    Uses
    • It is used to treat schizophrenia. It may take 6 weeks to see the full effect.
    • It is used to treat problems with how one acts.
    • Clozapine helps clear thinking.
    • It works on helping social interactions, mood, expression of mood, as well as, delusions, paranoia, and look.

    Dosing

    How to take

    • Take with or without food. Take with food if it causes an upset stomach.
    • Oral-disintegrating tablet: Do not push the tablet out of the foil when opening. Use dry hands to take it from the foil. Place on your tongue and let it melt. Water is not needed. Do not swallow it whole. Do not chew, break, or crush it.
    • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • If you miss 2 or more days of this drug, call your doctor to find out how to restart.
    • Do not take 2 doses at the same time or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.

    Storage

    • Store at room temperature.
    • Protect from water. Do not store in a bathroom or kitchen.
    • Use oral-disintegrating tablet right after opening. Throw away any part of opened pouch that is not used.

    Safety



    Warnings

    • Unsafe blood cell problems may happen. Report any fever, sore throat, mouth sores, infections, easy bruising, or purple "splotches" on your skin to your doctor right away. Follow what the doctor tells you about blood tests while taking this drug. These tests are needed.
    • If you have a history of seizures, head injury, or brain tumor, your chance of having a seizure may be higher if taking a large dose of this drug every day. Stopping some drugs all of a sudden, a sudden change in drinking alcohol, or taking some drugs may raise the chance of seizures. Check all drugs with your doctor.
    • This drug may cause harm to your heart sometimes. It may cause low blood pressure or a fast heartbeat. Talk with your doctor.
    • There is a higher chance of death in older adults who take this drug for memory problems (dementia).
    • Unsafe side effects may happen. This drug cannot be taken while you are taking some other drugs. Check all the drugs you are taking with your doctor.

    Avoid

    • If you have an allergy to clozapine or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Bowel block, low white blood cell count, or seizures.
    • If you are breast-feeding.

    Precautions

    • If you are 65 or older, use this drug with care. You could have more side effects.
    • If you have PKU, talk with your doctor. The oral-disintegrating tablet has phenylalanine.
    • If you have high blood sugar (diabetes), talk with your doctor. This drug may raise blood sugar.
    • Check your blood sugar as you have been told by your doctor.
    • If you have heart disease, talk with your doctor.
    • If you have liver disease, talk with your doctor.
    • If you have lung disease, talk with your doctor.
    • If you smoke, talk with your doctor.
    • Have your blood pressure and heart rate checked often. Talk with your doctor.
    • Have your blood work checked often. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • You may not be alert. Avoid driving and doing other tasks or actions until you see how this drug affects you.
    • Avoid beer, wine, mixed drinks, or other drugs and natural products that slow your actions.
    • Be careful in hot weather. Drink lots of fluids to stop fluid loss.
    • Tell your doctor if you are pregnant or plan on getting pregnant.

    Side Effects

    • High blood sugar. This most often goes back to normal when drug is stopped.
    • Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.
    • Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing.
    • Nervous and excitable.
    • Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative.
    • Weight gain.
    • Change in sex ability. This most often goes back to normal.
    • Drooling when sleeping.
    • Harm to the heart may rarely happen.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
    • Very bad dizziness or passing out.
    • Trouble breathing.
    • A fast heartbeat.
    • Big change in balance.
    • Very bad headache.
    • Feeling very tired or weak.
    • Very bad swelling.
    • A big weight gain.
    • More trips to the bathroom, more thirst, or weight loss.
    • For women, if you get pregnant while taking this drug.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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