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Guaifenesin and Dextromethorphan


Related terms
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    Related terms
    • U.S. Brand Names: Allfen DM [OTC] [DSC];Cheracol® D [OTC];Cheracol® Plus [OTC];Coricidin HBP® Chest Congestion and Cough [OTC];Diabetic Siltussin-DM DAS-Na Maximum Strength [OTC];Diabetic Siltussin-DM DAS-Na [OTC];Diabetic Tussin® DM Maximum Strength [OTC];Diabetic Tussin® DM [OTC];Double Tussin DM [OTC];Fenesin DM IR;Gani-Tuss DM NR [DSC];Guaicon DM [OTC] [DSC];Guaicon DMS [OTC];Guia-D [DSC];GuiadrineT DX [DSC];Kolephrin® GG/DM [OTC];Mintab DM [DSC];Mucinex® DM Maximum Strength [OTC];Mucinex® DM [OTC];Mucinex® Kid's Cough Mini-MeltsT [OTC];Mucinex® Kid's Cough [OTC];RefenesenT DM [OTC];Robafen DM Clear [OTC];Robafen DM [OTC];Robitussin® Cough & Chest Congestion DM Max [OTC];Robitussin® Cough & Chest Congestion DM [OTC];Robitussin® Cough & Chest Congestion Sugar-Free DM [OTC];Safe Tussin® DM [OTC];Scot-Tussin® Senior [OTC];Silexin [OTC];Siltussin DM DAS [OTC];Siltussin DM [OTC];Simuc-DM [DSC];Su-Tuss DM [DSC];Tussi-Bid®;Vicks® 44E [OTC];Vicks® DayQuil® Mucus Control DM [OTC];Vicks® Pediatric Formula 44E [OTC]
    • Canadian Brand Names: Balminil DM E;Benylin® DM-E;Koffex DM-Expectorant;Robitussin® DM
    • Mexican Brand Names: Bre-A-Col;Cheracol D;Debequin C;Dequin;Dexometorfano-Guaifenesina;Dimacol;Exiadol;Megal;Robitussin DM;Tukol D
    • Pharmacologic Category: Antitussive;Cough Preparation;Expectorant

    • It is used to thin secretions so they can be removed from the body by coughing.
    • Guaifenesin thins fluids in the lungs.
    • Dextromethorphan affects the cough center in the brain.


    How to take

    • Take with a full glass of water.
    • Drink plenty of noncaffeine-containing liquid unless told to drink less liquid by doctor.
    • Long-acting products: Swallow whole. Do not chew, break, or crush.
    • There is a liquid (syrup) if you cannot swallow pills.
    • Those who have feeding tubes can also use the liquid. Flush the feeding tube before and after this drug is given.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to time for the next dose, skip the missed dose and return to your normal time.
    • Do not take two doses or extra doses.
    • Many times this drug is taken on an as needed basis.


    • Store at room temperature.
    • Protect from light.
    • Protect capsules and tablets from water. Do not store in a bathroom or kitchen.



    • Talk with doctor before giving this drug to a child. Check all of your child's drugs, including OTC, with doctor.
    • Unsafe reactions may happen. This drug cannot be taken while you are taking certain other drugs. Check all the drugs you are taking with your doctor.


    • If you have an allergy to guaifenesin, dextromethorphan, or any other part of this drug.
    • Tell doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs involved.
    • If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this drug is started. Taking the two at the same time could cause risky high blood pressure.


    • This drug is not for coughs due to smoking or lung disease.
    • Check all drugs you are taking with your doctor. This drug may not mix well with certain other drugs.
    • If you have PKU, talk with doctor. Some products do contain phenylalanine.
    • Tell doctor if you are pregnant or plan on getting pregnant.
    • Tell doctor if you are breast-feeding.

    Side Effects

    • Feeling dizzy. Rise slowly over a few minutes from sitting or lying position. Be careful climbing.
    • Headache.
    • Upset stomach or throwing up. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.


    • Change in health problem being treated. Is it better, worse, or about the same?

    Contact a healthcare provider

    • If you suspect an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Cough that does not go away.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada return any unused drugs back to the pharmacy. Also, visit for more facts about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, supplements, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for health help about side effects. You may also call the FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
    • Talk with doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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