Table of Contents > Drug > Hydroxyurea Print

Hydroxyurea

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Droxia®;Hydrea®
    • Brand Names: Canada: Apo-Hydroxyurea®;Gen-Hydroxyurea;Hydrea®;Mylan-Hydroxyurea
    • Mexican Brand Names: Hydrea
    • Pharmacologic Category: Antineoplastic Agent, Antimetabolite

    Uses
    • It is used to treat blood problems.
    • It is used to treat some cancers.
    • It is used to treat sickle cell anemia.
    • Hydroxyurea harms cancer cells causing their death.
    • It lowers blood cell counts.
    • It lowers painful crisis and the number of blood transfusions.

    Dosing

    How to take

    • Use as you have been told, even if you are feeling better.
    • A liquid may be made if you cannot swallow capsules.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.

    Storage

    • Store at room temperature.
    • Protect from water. Do not store in a bathroom or kitchen.
    • You must handle and throw away this drug the right way. If powder from the capsule is spilled, wipe it up with a damp, throw away towel right away. Throw away the towel in a closed holder, such as a plastic bag. Wash your hands fully.

    Safety



    Warnings

    • Hydroxyurea may cause changes in cells and may raise the chance of cancer when used to treat blood problems. It may also cause very bad side effects. Talk with your doctor about the good and bad effects.
    • Unsafe side effects may happen. This drug cannot be taken while you are taking some other drugs. Check all the drugs you are taking with your doctor.

    Avoid

    • If you have an allergy to hydroxyurea or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Anemia or bone marrow disease.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.

    Precautions

    • If you have kidney disease, talk with your doctor.
    • If you have irritation of the mucous membranes (for example, lining of the mouth, throat, nostrils, stomach, bowel), talk with your doctor.
    • If you have ever had radiation, talk with your doctor.
    • Have your blood work checked often. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Talk with your doctor before getting any vaccines. Use with this drug may either raise the chance of a very bad infection or make the vaccine not work as well.
    • If you have HIV and are taking didanosine and/or stavudine, talk with your doctor.
    • Use birth control that you can trust to stop pregnancy while taking this drug.

    Side Effects

    • Anemia, low white blood cell count, and low platelet count.
    • Headache.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Not hungry.
    • Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative.
    • Loose stools.
    • Mouth irritation. Using a soft toothbrush or cotton swabs and rinsing the mouth may help.
    • Swelling.
    • Skin changes (pimples, stretch marks, slow healing, hair growth).
    • Muscle weakness.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
    • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
    • Seizures.
    • Change in thinking clearly and with logic.
    • Very bad belly pain.
    • Very upset stomach or throwing up.
    • Very hard stools (constipation).
    • Mouth sores.
    • Any bruising or bleeding.
    • Feeling very tired or weak.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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