Table of Contents > Drug > Penicillamine Print

Penicillamine

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Cuprimine®;Depen®
    • Brand Names: Canada: Cuprimine®;Depen®
    • Mexican Brand Names: Adalken
    • Pharmacologic Category: Chelating Agent

    Uses
    • It is used to treat Wilson's disease.
    • It is used to get rid of a protein called cystine from the body.
    • It is used to treat arthritis.
    • It is used to take some metals from the body.
    • Penicillamine helps get rid of cystine from your body.
    • It binds with some types of metals to take them from the body.
    • It lowers the body's harmful response to diseases of the immune system.

    Dosing

    How to take

    • To gain the most benefit, do not miss doses.
    • Take on an empty stomach. Take 1 hour before or 2 hours after meals.
    • There is a liquid (suspension) if you cannot swallow pills. Shake well before use.
    • Those who have feeding tubes may also use the liquid. Flush the feeding tube before and after this drug is given.
    • For patients who have feeding tubes, open the capsule and mix with 3 tablespoons (45 mL) of apple juice. Give in the feeding tube. Flush the feeding tube before and after this drug is given.
    • Take vitamin B6 (pyridoxine) as you were told by your doctor.
    • Follow the diet and workout plan that your doctor told you about.
    • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.

    Storage

    • Store capsules and tablets at room temperature.
    • Protect capsules and tablets from water. Do not store in a bathroom or kitchen.
    • Store liquid (suspension) at room temperature or in a refrigerator. Throw away any part not used after 1 month.

    Safety



    Warnings

    • This drug is very strong. It may stop your bone marrow from making some of the cells that your body needs. You will be closely watched by your doctor. Tell your doctor right away about any fever, sore throat, signs of infection, bleeding, shortness of breath, or feeling tired.

    Avoid

    • If you have an allergy to penicillamine or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.

    Precautions

    • If you have a penicillin allergy, talk with your doctor.
    • Have your blood work checked often. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Do not take dairy products, bismuth (Pepto-Bismol®), calcium, iron, magnesium, zinc, multivitamins with minerals, colestipol, cholestyramine, didanosine, or antacids within 2 hours of this drug.
    • Tell dentists, surgeons, and other doctors that you use this drug.
    • Take good care of your teeth. See a dentist often.
    • Use birth control that you can trust to stop pregnancy while taking this drug.

    Side Effects

    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Bad taste in your mouth. This most often goes back to normal.
    • Not hungry.
    • Muscle weakness.
    • Itching.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
    • Trouble breathing.
    • Very upset stomach or throwing up.
    • Very bad muscle pain or weakness.
    • Any bruising or bleeding.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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